AMSM - Papers (since 1991)

Magnetic Resonance Spectroscopy and Methodology


Department of Clinical Research


Department of Diagnostic, Interventional, and Pediatric Radiology


University Bern/Switzerland

For copyright reasons, articles are not generally available in full text versions. Exceptions are indicated.
Three educational articles are available online:
Kreis R. 1H MR Spectroscopy: Clinical Applications. Syllabus (pdf-file in English)

Boesch C. Magnetresonanz-Spektroskopie in vivo. Labor und Medizin 24: 245-253 (1997) (html-file in German)

Kreis R. 1H MR Spectroscopy Outside the Brain. Syllabus (pdf-file in English)

·            Kyathanahally SP, Mocioiu V, Pedrosa de Barros NM, Slotboom J, Wright AJ, Julia-Sape M, Arus C, Kreis R. Quality of clinical brain tumor MR spectra judged by humans and machine learning tools. Magn.Reson.Med. [in press] (2017).

·            Giapitzakis IA, Shao T, Avdievich N, Mekle R, Kreis R, Henning A. Metabolite-cycled STEAM and semi-LASER localization for MR spectroscopy of the human brain at 9.4T. Magn.Reson.Med.[Epub ahead of print]: doi: 10.1002/mrm.26873 (2017).

·          Adalid V, Döring A, Kyathanahally SP, Bolliger CS, Boesch C, Kreis R. Fitting interrelated datasets: metabolite diffusion and general lineshapes. Magn.Reson.Mater.Phy. ePub: DOI 10.1007/s10334-017-0618-z (2017).

·          Bally L, Kempf P, Zueger T, Speck C, Pasi N, Ciller C, Feller K, Loher H, Rosset R, Wilhelm M, Boesch C, Buehler T, Dokumaci AS, Tappy L, Stettler C. Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes. Nutrients 9: E164; doi: 10.3390/nu9020164 (2017).

·          Barbieri S, Bronnimann M, Boxler S, Vermathen P, Thoeny HC. Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI. Eur.Radiol. 27: 1547-1555 (2017).

·          Campos V, Despland C, Brandejsky V, Kreis R, Schneiter P, Boesch C, Tappy L. Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial. Nutrients 9: E202; doi: 10.3390/nu9030202 (2017).

·          Diserens G, Hertig D, Vermathen M, Legeza B, Fluck CE, Nuoffer JM, Vermathen P. Metabolic stability of cells for extended metabolomical measurements using NMR. A comparison between lysed and additionally heat inactivated cells. Analyst 142: 465-471 (2017).

·          Fichtner ND, Henning A, Zoelch N, Boesch C, Kreis R. Elucidation of the downfield spectrum of human brain at 7T using multiple inversion recovery delays and echo times. Magn.Reson.Med. 78: 11-19 (2017).

·          Kyathanahally SP, Franco-Watkins A, Zhang X, Calhoun VD, Deshpande G. A Realistic Framework for Investigating Decision Making in the Brain With High Spatiotemporal Resolution Using Simultaneous EEG/fMRI and Joint ICA. IEEE J.Biomed.Health Inform. 21: 814-825 (2017).

·          Lee S, Kuk JL, Boesch C, Arslanian S. Waist circumference is associated with liver fat in black and white adolescents. Appl.Physiol.Nutr.Metab. 42: 829-833 (2017).

·          Levy PL, Duponchel S, Eischeid H, Molle J, Michelet M, Diserens G, Vermathen M, Vermathen P, Dufour JF, Dienes HP, Steffen HM, Odenthal M, Zoulim F, Bartosch B. Hepatitis C virus infection triggers a tumor-like glutamine metabolism. Hepatology 65: 789-803 (2017).

·          Pouymayou B, Buehler T, Kreis R, Boesch C. Test-retest analysis of multiple 31P magnetization exchange pathways using asymmetric adiabatic inversion. Magn.Reson.Med.  78: 33-39 (2017).

·          Rosset R, Lecoultre V, Egli L, Cros J, Dokumaci AS, Zwygart K, Boesch C, Kreis R, Schneiter P, Tappy L. Postexercise repletion of muscle energy stores with fructose or glucose in mixed meals. Am.J.Clin.Nutr. 105: 609-617 (2017).

·          Vermathen M, Marzorati M, Diserens G, Baumgartner D, Good C, Gasser F, Vermathen P. Metabolic profiling of apples from different production systems before and after controlled atmosphere (CA) storage studied by 1H high resolution-magic angle spinning (HR-MAS) NMR. Food Chem. 233: 391-400 (2017).

·          Vermathen M, Diserens G, Vermathen P, Furrer J. Metabolic Profiling of Cells in Response to Drug Treatment using 1H High-resolution Magic Angle Spinning (HR-MAS) NMR Spectroscopy. Chimia 71: 124-129 (2017).

·          Vermathen P. Diffusion MRI and MRS outside the brain: from methodology to practice. NMR Biomed. 30: doi: 10.1002/nbm.3703. (2017).

·          Kyathanahally SP, Kreis R. Forecasting the quality of water-suppressed 1 H MR spectra based on a single-shot water scan. Magn.Reson.Med. [Epub ahead of print]: doi: 10.1002/mrm.26389. (2016).

·          Zueger T, Loher H, Egger A, Boesch C, Christ E. Regulation of fuel metabolism during exercise in hypopituitarism with growth hormone-deficiency (GHD). Growth Horm IGF Res 29: 39-44 (2016).

·          Loher H, Kreis R, Boesch C, Christ E. The flexibility of ectopic lipids. Int J Mol Sci 17: 1554; doi:10.3390/ijms17091554 (2016).

·          Diserens G, Vermathen M, Gjuroski I, Eggimann S, Boesch C, Vermathen P. Direct determination of phosphate sugars in biological material by 1H High Resolution Magic-Angle-Spinning NMR spectroscopy. Anal Bioanal Chem 408: 5651-5656 (2016).

·          Boesch C and Kreis R. Muscle Studies by 1H MRS. eMagRes 5: 1097-1108 (2016).

·          Buehler T, Bally L, Dokumaci AS, Stettler C, Boesch C. Methodological and physiological test-retest reliability of 13C-MRS glycogen measurements in liver and in skeletal muscle of patients with type 1 diabetes and matched healthy controls. NMR Biomed 29: 796-805 (2016).

·          Christ ER, Egger A, Allemann S, Buehler T, Kreis R, Boesch C. Effects of aerobic exercise on ectopic lipids in patients with growth hormone deficiency before and after growth hormone replacement therapy. Sci.Rep. 6: 19310 (2016).

·          Bally L, Zueger T, Buehler T, Dokumaci AS, Speck C, Pasi N, Carlos C, Paganini D, Feller K, Loher H, Rosset R, Wilhelm M, Tappy L, Boesch C, Stettler C. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes - randomised cross-over study. Diabetologia. 59:776-84 (2016).

·          Seif M, Mani L, Lu H, Boesch C, Reyes M, Vogt B, Vermathen P. Diffusion tensor imaging of the human kidney: Does image registration permit scanning without respiratory triggering? J Magn Reson Imaging 44: 327-334 (2016).

·          Valenzuela W, Ferguson SJ, Ignasiak D, Diserens G, Vermathen P, Boesch C, Reyes M (2015) Correction tool for Active Shape Model based lumbar muscle segmentation. Conf Proc IEEE Eng Med Biol Soc 2015: 3033-3036 (2015).

·          MacMillan E, Bolliger C, Boesch C, Kreis R. Influence of muscle fibre orientation on water and metabolite relaxation times, magnetization transfer, and visibility in human skeletal muscle. Magn.Reson.Med. 75: 1764-1770 (2016).

·          Seif M, Eisenberger U, Binser T, Thoeny HC, Krauer F, Boesch C, Vogt B, Vermathen P. Renal Blood Oxygenation Level-Dependent Imaging in Longitudinal Follow-up of the Donated and the Remaining Kidneys. Radiology 279: 795-804 (2016).

·          Dokumaci AS, Pouymayou B, Kreis R, Boesch C. Motion-Insensitive Determination of B1+ Amplitudes Based on the Bloch-Siegert Shift in Single Voxels of Moving Organs Including the Human Heart. Magn.Reson.Med. 75: 1867-1874 (2016).

·          Kreis R. The trouble with quality filtering based on relative Cramér-Rao lower bounds. Magn Reson Med 75: 15-18 (2016).

·          Campos V, Despland C, Brandejsky V, Kreis R, Schneiter P, Chiolero A, Boesch C, Tappy L. Sugar-sweetened and artificially sweetened beverages and intrahepatic fat in overweight subjects: a randomized controlled trial. Obesity 23: 2335-2339 (2015).

·          Precht C, Diserens G, Oevermann A, Vermathen M, Lang J, Boesch C, Vermathen P. Variability of lipid resonances in HR-MAS spectra of brain biopsies subject to spinning rate variation. Biochim.Biophys.Acta 1851: 1539-1544 (2015).

·          Kyathanahally SP, Fichtner ND, Adalid V, Kreis R. Does superficial fat affect metabolite concentrations determined by MR spectroscopy with water referencing? NMR Biomed 28: 1543-1549 (2015).

·          Broskey NT, Boss A, Fares EJ, Greggio C, Gremion G, Schlüter L, Hans D, Kreis R, Boesch C, Amati F. Exercise efficiency relates with mitochondrial content and function in older adults. Physiol Rep. 3 pii: e12418 (2015).

·          Bally L, Buehler T, Dokumaci AS, Boesch C, Stettler C. Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls. Diabetes Res Clin Pract. 109:e1-3 (2015).

·          Vermathen M, Paul LE, Diserens G, Vermathen P, Furrer J. 1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug. PLoS One.10:e0128478 (2015).

·          Buehler T, Kreis R, Boesch C. Comparison of 31P saturation and inversion magnetization transfer in human liver and skeletal muscle using a clinical MR-system and surface coils. NMR Biomed 28: 188-199 (2015).

·          Diserens G, Vermathen M, Precht C, Broskey NT, Boesch C, Amati F, Dufour JF, Vermathen P. Separation of small metabolites and lipids in spectra from biopsies by diffusion-weighted HR-MAS NMR: a feasibility study. Analyst 140: 272-279 (2015).

·          Brandejsky V, Boesch C, Kreis R. Proton diffusion tensor spectroscopy of metabolites in human muscle in vivo. Magn Reson Med 73: 481-487 (2015).

·          Lee SJ, Rivera-Vega M, Alsayed HMAA, Boesch C, Libman I. Metabolic inflexibility and insulin resistance in obese adolescents with nonalcoholic fatty liver disease. Pediatr Diabetes 16: 211-218 (2015).

·          Seif M, Lu H, Boesch C, Reyes M, Vermathen P. Image registration for triggered and non-triggered DTI of the human kidney: Reduced variability of diffusion parameter estimation. J.Magn.Reson.Imaging 41: 1228-1235 (2015).

·          Thoeny HC, Froehlich JM, Triantafyllou M, Huesler J, Bains LJ, Vermathen P, Fleischmann A, Studer UE. Metastases in normal-sized pelvic lymph nodes: detection with diffusion-weighted MR imaging. Radiology. 273:125-135 (2014).

·          Ith M, Stettler C, Xu J, Boesch C, Kreis R. Cardiac lipids show diurnal changes and long-term variations in healthy human subjects. NMR Biomed 27: 1285-1292 (2014).

·          Lecoultre V, Carrel G, Egli L, Binnert C, Boss A, MacMillan EL, Kreis R, Boesch C, Darimont C, Tappy L. Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men. Am.J.Clin.Nutr. 99: 268-275 (2014).

·          Giannarini G, Kessler TM, Roth B, Vermathen P, Thoeny HC. Functional Multiparametric Magnetic Resonance Imaging of the Kidneys Using Blood Oxygen Level-Dependent and Diffusion-Weighted Sequences: a Reliable Tool for Monitoring Acute Upper Urinary Tract Obstruction. J Urol 192: 434-439 (2014).

·          Bucher J, Kruesi M, Zueger T, Ith M, Stettler C, Diem P, Boesch C, Kreis R, Christ E. The effect of a single bout of a 2h aerobic exercise on ectopic lipids in skeletal muscle, liver and the myocardium. Diabetologia 57: 1001-1005 (2014).

·          Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, Hans D, Gremion G, Kreis R, Boesch C, Canto C, Amati F. Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. J Clin Endocrinol Metab 99 : 1852-1861 (2014).

·          Homan P, Vermathen P, van Swam C, Federspiel A, Boesch C, Strik WK, Hubl D, Kreis R. Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations. Neuroimage 94: 23-32 (2014).

·          Maquer G, Brandejsky V, Benneker LM, Watanabe A, Vermathen P, Zysset PK. Human intervertebral disc stiffness correlates better with the Otsu threshold computed from axial T map of its posterior annulus fibrosus than with clinical classifications. Med Eng Phys 36: 219-225 (2014).

·          Reutlinger C, Burki A, Brandejsky V, Ebert L, Buchler P. Specimen specific parameter identification of ovine lumbar intervertebral discs: On the influence of fibre-matrix and fibre-fibre shear interactions. J Mech Behav Biomed Mater 30: 279-289 (2014).

·          Ulbrich EJ, Schraner C, Boesch C, Hodler J, Busato A, Anderson SE, Eigenheer S, Zimmermann H, Sturzenegger M. Normative MR Cervical spinal canal dimensions. Radiology 271:183-192 (2014).

·          Eisenberger U, Binser T, Thoeny HC, Boesch C, Frey FJ, Vermathen P. Diffusion-Weighted MRI in Living Renal Allograft Transplantation: Longitudinal Follow-up of the Donated and the Remaining Kidney. Radiology 270:800-808 (2014).

·          Öz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dincer A, Dydak U, Emir UE, Frahm J, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Özduman K, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJW, Ratai EM, Ross BD, Scheenen TWJ, Schuster C, Soher BJ, Tkac I, Vigneron DB, Kauppinen RA. Clinical Proton MR Spectroscopy in Central Nervous System Disorders. Radiology 270:658-679 (2014).

·          Ulbrich EJ, Anon J, Hodler J, Busato A, Zimmermann H, Sturzenegger M, Anderson SE, Boesch C. Does normalized signal intensity of cervical discs on T2 weighted MRI images change in whiplash patients? Injury 45:784-791 (2014).

·          Desplanches D, Schmutz S, Mueller M, Hoppeler H, Kreis R, Flück M. Hypoxia refines plasticity of mitochondrial respiration to repeated muscle work. Eur.J.Appl.Physiol. 114:405-417 (2014).

·          Gross M, Boesch C, Bolliger CS, Norman B, Gustafsson T, Hoppeler H, Vogt M. Effects of beta-alanine supplementation and interval training on physiological determinants of severe exercise performance. Eur.J.Appl.Physiol. 114:221-234 (2014).

·          Boesch C. MR Spectroscopy and Spectroscopic Imaging for Evaluation of Skeletal Muscle Metabolism: Basics and Applications in Metabolic Diseases. In: Weber MA (ed) Magnetic Resonance Imaging of the Skeletal Musculature. Spinger: Berlin ISSN/ISBN 978-3-642-37219-3 pp.135-163 (2014).

·          Birkhauser FD, Studer UE, Froehlich JM, Triantafyllou M, Bains LJ, Petralia G, Vermathen P, Fleischmann A, Thoeny HC. Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging facilitates detection of metastases in normal-sized pelvic lymph nodes of patients with bladder and prostate cancer. Eur.Urol. 64:953-960 (2013).

·          Lee SJ, Deldin AR, White D, Libman I, Rivera-Vega M, Kuk JL, Sandoval S, Boesch C, Arslanian S. Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls. Am.J.Physiol. 305: E1222–E1229 (2013).

·          Bolliger C, Boesch C, Kreis R. On the Use of Cramér-Rao Minimum Variance Bounds for the Design of Magnetic Resonance Spectroscopy Experiments, NeuroImage 83: 1031-1040 (2013).

·          Egger A, Allemann S, Stettler C, Diem P, Buehler T, Kreis R, Boesch C, Christ ER. The Effect of Aerobic Exercise on Intrahepatocellular and Intramyocellular Lipids in Physically Active Healthy Subjects. PLoS One 8: e70865 (2013).

·          Lecoultre V, Egli L, Carrel G, Theytaz F, Kreis R, Schneiter P, Boss A, Zwygart K, Le KA, Bortolotti M, Boesch C, Tappy L. Effects of fructose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans. Obesity 21: 782-785 (2013).

·          Cariou B, Langhi C, Le Bras M, Bortolotti M, Lê KA, Bach K, Masson D, Le May C, Guyomarc'h-Delasalle B, Zair Y, Kreis R, Boesch C, Krempf M, Tappy L, Costet P. Circulating PCSK9 levels are associated with fructose-induced hypertriglyceridaemia and insulin resistance. Nutr.Metab. 10: 4 (2013).

·          Tshering Vogel DW, Zbaeren P, Geretschlaeger A, Vermathen P, De Keyzer F, Thoeny HC. Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers. Eur Radiol. 23: 562-569 (2013).

·          Lee S, Boesch C, Kuk JL, Arslanian S. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents. Metabolism 62: 417-423 (2013).

·          MacMillan E, Boesch C, Kreis R. Magnetization exchange observed in human skeletal muscle by non-water-suppressed proton magnetic resonance spectroscopy. Magn.Reson.Med. 70:916-924 (2013).

·          Hock A, Macmillan EL, Fuchs A, Kreis R, Boesiger P, Kollias SS, Henning A. Non-water-suppressed proton MR spectroscopy improves spectral quality in the human spinal cord. Magn.Reson.Med. 69: 1253-1260 (2013).

·          Rouffet D, Villars C, Fissoune R, Hautier C, Sappey-Marinier D, Laville M, Ibarrola D, Sothier M, Monnet MF, Ovize M, Bonnefoy M, Boesch C, Canet-Soulas E. Intramyocellular lipid variations in active older men: relationship with aerobic fitness. Acta Physiol. 207: 516-523 (2013).

·          Theytaz F, Noguchi Y, Egli L, Campos V, Buehler T, Hodson L, Patterson BW, Nishikata N, Kreis R, Mittendorfer B, Fielding B, Boesch C, Tappy L. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am.J.Clin.Nutr. 96:1008-1016 (2012).

·          Kreis R, Bolliger CS. The need for updates of spin system parameters, illustrated for the case of γ-aminobutyric acid. NMR Biomed. 25:1401-1403 (2012).

·          Vermathen M, Marzorati M, Vermathen P. Exploring high-resolution magic angle spinning (HR-MAS) NMR spectroscopy for metabonomic analysis of apples. Chimia (Aarau). 66:747-51 (2012).

·          Ulbrich EJ, Aeberhard R, Welti S, Busato A, Boesch C, Zimmermann H, Heini P, Hodler J, Anderson SE, Vock P, Sturzenegger M. Cervical muscle area measurements in whiplash patients – acute, 3 and 6 months follow-up. J.Magn.Reson.Imaging 36: 1413-1420 (2012).

·          Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes 61:2787-2795 (2012).

·          Buehler T, Ramseier N, Machann J, Schwenzer NF; Boesch C. Magnetic Resonance Imaging Based Determination of Body Compartments with the Versatile, Interactive Sparse Sampling (VISS) Method. J.Magn.Reson.Imaging 36:951-960 (2012).

·          van Swam C, Federspiel A, Hubl D, Wiest R, Boesch C, Vermathen P, Kreis R, Strik W, Dierks T. Possible Dysregulation of Cortical Plasticity in Auditory Verbal Hallucinations - A Cortical Thickness Study in Schizophrenia. J.Psychiatr.Res. 46: 1015-1023 (2012).

·          Bauer S, Ritacco LE, Boesch C, Nolte LP, Reyes M. Automatic Scan Planning for Magnetic Resonance Imaging of the Knee Joint. Ann. Biomed. Eng. 40:2033-2042 (2012).

·          Stellingwerff T, Decombaz J, Harris RC, Boesch C. Optimizing human in vivo dosing and delivery of beta-alanine supplements for muscle carnosine synthesis Amino Acids. Amino Acids 43: 57-65 (2012).

·          Boss A, Kreis R, Saillen P, Zehnder M, Boesch C, Vermathen P. Skeletal muscle 1H MRSI Before and After Prolonged Exercise II. Visibility of Free Carnitine. Magn.Reson.Med. 68:1368-1375 (2012).

·          Vermathen P, Saillen P, Boss A, Zehnder M, Boesch C. Skeletal muscle 1H MRSI Before and After Prolonged Exercise I. Muscle Specific Depletion of Intramyocellular Lipids. Magn.Reson.Med. 68:1357-1367 (2012).

·          Vermathen P, Binser T, Boesch C, Eisenberger U, Thoeny HC. Three Year Follow-up of Human Transplanted Kidneys by Diffusion-Weighted MRI and Blood Oxygenation Level-Dependent Imaging. J.Magn.Reson.Imaging 35:1133-1138 (2012).

·          Stellingwerff T, Anwander H, Egger A, Buehler T, Kreis R, Decombaz J, Boesch C. Effect of two b-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 42:2461-2472 (2012).

·          Froehlich J, Triantafyllou M, Fleischmann A, Vermathen P, Thalmann GN, Thoeny HC. Does quantification of USPIO uptake related signal loss allow differentiation of benign and malignant normal sized pelvic lymph nodes? Contrast Media Mol.Imaging 7:346-355 (2012).

·          Brandejsky V, Kreis R, Boesch C. In vivo proton MR spectroscopy shows restricted or severely hindered diffusion of intramyocellular lipids in human skeletal muscle. Magn.Reson.Med. 67: 310-316 (2012).

·          Mamisch TC, Hughes T, Mosher TJ, Mueller C, Trattnig S, Boesch C, Welsch GH. T2 star relaxation times for assessment of articular cartilage at 3 T: a feasibility study. Skeletal Radiol. 41: 287-292 (2012).

·          Anderson SE, Boesch C, Zimmermann H, Hodler J, Bingisser R, Ulbrich E, Nidecker A, Buitrago C, Bonel H, Heini P, Schaeren S, Busato A, Sturzenegger M. Are there cervical spine findings at MR imaging that are specific to acute symptomatic whiplash injury? A prospective controlled study with four experienced blinded readers. Radiology 262: 567-575 (2012).

·          Kreis R. 1H-Magnetic Resonance Spectroscopy of Cerebral Phenylalanine Content and its Transport at the Blood-Brain Barrier. In “Advances in Neurobiology. Ed. Lajtha A.. Vol. 4. Neural Metabolism in vivo. Eds. Choi I-Y., Gruetter R. Springer, New York ISBN 978-1-4614-1787-3 (2012).

·          Vermathen M, Marzorati M, Baumgartner D, Good C, Vermathen P. Investigation of Different Apple Cultivars by High Resolution Magic Angle Spinning NMR. A Feasibility Study. J.Agric.Food Chem. 59: 12784-12793 (2011).

·          Oosterhof R, Ith M, Trepp R, Christ ER, Flueck M. Regulation of whole body energy homeostasis with growth hormone replacement therapy and endurance exercise. Physiol Genomics 2011;43:739-748 (2011).

·          Decombaz J, Jentjens R, Ith M, Scheurer E, Buehler T, Jeukendrup A, Boesch C. Fructose and Galactose Enhance Post-Exercise Human Liver Glycogen Synthesis. Med.Sci.Sports Exerc. 43: 1964-1971 (2011).

·          Chong DGQ, Kreis R, Bolliger CS, Boesch C, Slotboom J. Two-dimensional linear-combination model fitting of magnetic resonance spectra to define the macromolecule baseline using FiTAID, a Fitting Tool for Arrays of Interrelated Datasets. Magn.Reson.Mater.Phy. 24: 147 - 164 (2011).

·          MacMillan E, Chong D, Dreher W, Henning A, Boesch C, Kreis R. Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T. Magn.Reson.Med.65:1239-1246 (2011).

·          Scheurer E, Lovblad KO, Kreis R, Maier SE, Boesch C, Dirnhofer R, Yen K. Forensic application of postmortem diffusion-weighted and diffusion tensor MRI of the human brain in situ. AJNR Am.J.Neuroradiol. 32: 1518-1524 (2011).

·          Ulbrich EJ, Anderson SE, Busato A, Abderhalden S, Boesch C, Zimmermann H, Heini P, Hodler J, Sturzenegger M. Cervical muscle area measurements in acute Whiplash patients and controls. J.Magn.Reson.Imaging 33: 668-675 (2011).

·          Ulbrich EJ, Eigenheer S, Boesch C, Hodler J, Busato A, Schraner C, Anderson SE, Bonel H, Zimmermann H, Vock P, Sturzenegger M. Alterations of the transverse ligament: an MRI study comparing acute whiplash patients with matched controls. AJR Am.J.Roentgenol. 197: 961-967 (2011).

·          Bortolotti M, Maiolo E, Corazza M, van Dijke E, Schneiter P, Boss A, Carrel G, Giusti V, Le KA, Chong DGQ, Buehler T, Kreis R, Boesch C, Tappy L. Effects of a whey protein supplementation on intra-hepatocellular lipids in obese female. Clin.Nutr. 30: 494-498 (2011).

·          Ith M, Scheurer E, Kreis R, Thali M, Dirnhofer R, Boesch C. Estimation of the postmortem interval by means of 1H magnetic resonance spectroscopy of decomposing brain tissue: influence of ambient temperature. NMR Biomed. 24: 791-798 (2011).

·          Kreis R, Wingeier K, Vermathen P, Giger E, Kaufmann F, Joncourt F, Zwygart K, Boesch C, Steinlin M. Brain Metabolite Composition in Relation to Cognitive Functioning and Dystrophin Mutations in Boys with Duchenne Muscular Dystrophy. NMR Biomed. 24: 253-262 (2011).

·          Wingeier K, Giger E, Strozzi S, Kreis R, Joncourt F, Conrad B, Gallati S, Steinlin M. Neuropsychological impairments and the impact of dystrophin mutations on general cognitive functioning of patients with Duchenne muscular dystrophy. J.Clin.Neurosci. 18: 90-95 (2011).

·          Boss A, Kreis R, Jenni S, Ith M, Nuoffer JM, Christ E, Boesch C, Stettler C. Non-invasive assessment of exercise-related intramyocellular acetylcarnitine in eu- and hyperglycemia in type 1 diabetic subjects using 1H-magnetic resonance spectroscopy. Diabetes Care 34: 220-222 (2011).

·          Egger A, Buehler T, Boesch C, Diem P, Stettler C, Christ ER. The Effect of Growth Hormone Replacement Therapy on Different Fat Compartments: A Whole Body Magnetic Resonance Imaging Study. Eur.J.Endocrinol. 164: 23-29 (2011).

·          Bruce SJ, Breton I, Decombaz J, Boesch C, Scheurer E, Montoliu I, Rezzi S, Kochhar S, Guy PA. A plasma global metabolic profiling approach applied to an exercise study monitoring the effects of glucose, galactose and fructose drinks during post-exercise recovery. J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. 878: 3015-3023 (2010).

·          Jann K, Kottlow M, Dierks T, Boesch C, Koenig T. Topographic electrophysiological signatures of FMRI Resting State Networks.  PLoS One 5: e12945 (2010).

·          Vermathen M, Marzorati M, Vermathen P, Bigler P. pH-dependent distribution of chlorin e6 derivatives across phospholipid bilayers probed by NMR spectroscopy. Langmuir 26:11085-94 (2010).

·          Sobrecases H, Lê KA, Bortolotti M, Schneiter P, Ith M, Kreis R, Boesch C, Tappy L. Effects of short-term overfeeding with fructose, fat, or fructose+fat on plasma and hepatic lipids in healthy males. Diabetes Metab. 36: 244-246 (2010).

·          Hubl D, Dougoud-Chauvin V, Zeller M, Federspiel A, Boesch C, Strik W, Dierks T, Koenig T. Structural Analysis of Heschl's Gyrus in Schizophrenia Patients with Auditory Hallucinations. Neuropsychobiology 61: 1-9 (2010).

·          Binser T, Thoeny HC, Eisenberger U, Stemmer A, Boesch C, Vermathen P. Comparison of physiological triggering schemes for diffusion-weighted magnetic resonance imaging in kidneys. J.Magn.Reson.Imaging 31: 1144-1150 (2010).

·          Jann K, Koenig T, Dierks T, Boesch C, Federspiel A. Association of individual resting state EEG alpha frequency and cerebral blood flow. Neuroimage. 51: 365-372 (2010).

·          Ith M, Huber PM, Egger A, Schmid JP, Kreis R, Christ E, Boesch C. Standardized protocol for a depletion of intramyocellular lipids (IMCL). NMR Biomed. 23:532-538 (2010).

·          Eisenberger U, Thoeny H, Binser T, Gugger M, Frey FJ, Boesch C, Vermathen P. Evaluation of Renal Allograft Function Early after Transplantation with Diffusion-Weighted MR Imaging. Eur.Radiol. 20: 1374-1383 (2010).

·          Ngo-Stock ET, Lê KA, Ith M, Kreis R, Boesch C, Tappy L. Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br.J.Nutr. 103:939-943 (2010).

·          Anderson SE, Boesch C, Zimmermann H, Busato A, Bingisser R, Hodler J, Heini P, Nidecker A, Bonel H, Ulbrich E, Buitrago-Tellez C, Schären S, Sturzenegger M. Schleudertrauma – die Jagd nach einem Phantom. Schweiz.Med.Forum 9 : 879-880 (2009).

·          Boesch C. "Human Muscle Studies by Magnetic Resonance Spectroscopy" in Encyclopedia of Magnetic Resonance, eds R. K. Harris and R. E. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm0225. Posted online 15th September 2009.

·          Ith M, Boesch C, Scheurer E. Investigation of decomposing sheep brain by means of 1H-MR-spectroscopy: An attempt towards an objective PMI estimation in the later postmortem period. In: Thali MJ, Dirnhofer R, Vock P (eds) The Virtopsy Approach: 3D Optical and Radiological Scanning and Reconstruction in Forensic Medicine. CRC Press, Taylor & Francis Group (2009).

·          Scheurer E, Bigler P, Ith M, Boesch C. Magnetic Resonance Spectroscopy in Forensic Medicine. In: Thali MJ, Dirnhofer R, Vock P (eds) The Virtopsy Approach: 3D Optical and Radiological Scanning and Reconstruction in Forensic Medicine. CRC Press, Taylor & Francis Group (2009).

·          Boesch C. Basics of MR imaging and spectroscopy. In: Thali MJ, Dirnhofer R, Vock P (eds) The Virtopsy Approach: 3D Optical and Radiological Scanning and Reconstruction in Forensic Medicine. CRC Press, Taylor & Francis Group (2009).

·          Thoeny HC, Triantafyllou M, Birkhaeuser FD, Froehlich JM, Tshering DW, Binser T, Fleischmann A, Vermathen P, Studer UE. Combined Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging Reliably Detect Pelvic Lymph Node Metastases in Normal-Sized Nodes of Bladder and Prostate Cancer Patients. Eur. Urol. 55: 761-769 (2009).

·          Thoeny HC, Binser T, Roth B, Kessler TM, Vermathen P. Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study. Radiology 252: 721-728 (2009).

·          Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M, Ith M, Vermathen P, Stefanoni N, Le KA, Schneiter P, Kempf R, Vidal H, Boesch C, Tappy L. High protein intake reduces intrahepatocellular lipids deposition in humans. Am.J.Clin.Nutr. 90: 1002-1010 (2009).

·          Lê KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, Boesch C, Tappy L. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am.J.Clin.Nutr. 89: 1760-1765 (2009).

·          Watanabe A, Boesch C, Anderson SE, Brehm W, Mainil P. Ability of dGEMRIC and T2 mapping to evaluate cartilage repair after microfracture: A goat study. Osteoarthr.Cartilage 17: 1341-1349 (2009).

·          Kreis R, Zwygart K, Boesch C, Nuoffer,J.M. Reproducibility of Cerebral Phenylalanine Levels in Patients with Phenylketonuria Determined by 1H-MR Spectroscopy, Magn.Reson.Med. 62: 11-16 (2009).

·          Jann K, Dierks T, Boesch C, Kottlow M, Strik W, Koenig T. BOLD correlates of EEG alpha phase-locking and the fMRI default mode network. NeuroImage 45: 903-916 (2009).

·          Boesch C, Vermathen P, Kreis R. Insufficient Spectral Quality to Draw Conclusions (Letter) Radiology 250: 955-956 (2009).

·          Boesch C. Magic angle spinning magnetic resonance - a novel method opening up translational research into NAFLD? (Editorial) Clin.Sci. 116: 401-402 (2009).

·          Vermathen M, Vermathen P, Simonis U, Bigler P. Time-Dependent Interactions of the Two Porphyrinic Compounds Chlorin e6 and Mono-L-aspartyl-chlorin e6 with Phospholipid Vesicles Probed by NMR Spectroscopy. Langmuir 24: 12521-12533 (2008).

·          Anon J, Remonda L, Spreng A, Scheurer E, Schroth G, Boesch C, Thali M, Dirnhofer R, Yen K. Traumatic Extra-Axial Hemorrhage: Correlation of Postmortem MSCT, MRI and Forensic-Pathological Findings. J.Magn.Reson.Imaging 28: 823-836 (2008).

·          Jann K, Wiest R, Hauf M, Meyer K, Boesch C, Mathis J, Schroth G, Dierks T, Koenig T. BOLD correlates of continuously fluctuating epileptic activity isolated by independent component analysis. NeuroImage 42: 635-648 (2008).

·          Jenni S, Oetliker C, Allemann S, Ith M, Tappy L, Wuerth S, Egger A, Boesch C, Schneiter Ph, Diem P, Christ E, Stettler C. Fuel Metabolism During Exercise in Eu- and Hyperglycaemia in Subjects with Type 1 Diabetes Mellitus - a Prospective Single-Blinded Randomised Cross-Over Trial. Diabetologia 51 (1457-1465 (2008).

·          Trepp R, Fluck M, Stettler C, Boesch C, Ith M, Kreis R, Hoppeler H, Howald H, Schmid JP, Diem P, Christ ER. The Effect of Growth Hormone (GH) on Human Skeletal Muscle Lipid Metabolism in GH-Deficiency. Am.J.Physiol. 294: E1127-E1134 (2008).

·          Thoeny HC, Kessler TM, Simon-Zoula S, De Keyzer F, Mohaupt M, Studer UE, Vermathen P. Renal Oxygenation Changes During Acute Unilateral Ureteral Obstruction Assessed by Blood Oxygen Level-Dependent (BOLD) MR Imaging: Initial Experience. Radiology 247: 754-761 (2008).

·          Andreisek G, Froehlich JM, Hodler J, Weishaupt D, Beutler V, Pfirrmann CWA, Boesch C, Nanz D. Direct MR arthrography at 1.5 T and 3.0 T: Signal dependence on gadolinium and iodine concentrations. Radiology 247: 706-716 (2008).

·          Simon-Zoula SC, Boesch C, De Keyzer F, Thoeny HC. Functional imaging of the parotid glands using blood oxygenation level dependent (BOLD)-MRI at 1.5T and 3T. J.Magn Reson.Imaging 27: 43-48 (2008).

·          Lê KA, Faeh D, Stettler R, Debard C, Loizon E, Vidal H, Boesch C, Ravussin E, Tappy L. Effects of four-week high fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 34: 82-85 (2008).

·          Vermathen P, Robert-Tissot L, Pietz J, Lutz T, Boesch C, Kreis R. Characterization of White Matter Alterations in Phenylketonuria by Magnetic Resonance Relaxometry and Diffusion Tensor Imaging. Magn.Reson.Med. 58: 1145-1156 (2007).

·          Watanabe A, Benneker LM, Boesch C, Watanabe T, Takyuki O, Anderson SE. Classification of intervertebral disc degeneration with axial T2 mapping. AJR Am.J.Roentgenol. 189: 936-942 (2007).

·          Yen K, Lovblad KO, Scheurer E, Ozdoba C, Thali MJ, Aghayev E, Jackowski C, Anon J, Frickey N, Zwygart K, Weis J, Dirnhofer R. Post-mortem forensic neuroimaging: Correlation of MSCT and MRI findings with autopsy results. Forensic Sci.Int. 173: 21-35 (2007).

·          Yen K, Vock P, Christe A, Scheurer E, Plattner T, Schon C, Aghayev E, Jackowski C, Beutler V, Thali MJ, Dirnhofer R. Clinical forensic radiology in strangulation victims: forensic expertise based on magnetic resonance imaging (MRI) findings. Int.J.Legal Med. 121: 115-123 (2007).

·          Watanabe A, Boesch C, Siebenrock K, Obata T, Anderson SE. T2 mapping of hip articular cartilage in healthy volunteers at 3T: A study of topographic variation. J.Magn.Reson.Imaging; 26: 165-171 (2007).

·          Watanabe A, Boesch C, Obata T, Anderson SE. Effect of multislice acquisition on T1 and T2 measurements of articular cartilage at 3T. J.Magn.Reson.Imaging 26: 109-117 (2007).

·          Scheurer E, Ith M, Boesch C. Application of MRS in forensic pathology. In: Rapley R, Whitehouse D (eds) Molecular Forensics. John Wiley & Sons, Ltd.: Chichester UK 222-239 (2007)

·          Boesch C, Musculoskeletal Spectroscopy, J.Magn,Reson.Imaging 25:321-338 (2007).

·          Lê KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, Boesch C, Ravussin E, Tappy L. Effects of a 4-week high fructose diet on insulin sensitivity and ectopic lipids. Am.J.Clin.Nutr. 84:1374-1379 (2006).

·          Boesch C, Machann J, Vermathen P, Schick F. Role of Proton MR for the Study of Muscle Lipid Metabolism. NMR Biomed. 19: 968-988 (2006).

·          Thoeny HC, Zumstein D, Simon-Zoula S, Eisenberger U, De Keyzer F, Hofmann L, Vock P, Boesch C, Frey FJ, Vermathen P. Functional Evaluation of Transplanted Kidneys by Diffusion-Weighted Magnetic Resonance Imaging and Blood Oxygenation Level-Dependent Imaging: Initial Experience. Radiology 241: 812-821 (2006).

·          Zehnder M, Christ ER, Ith M, Acheson KJ, Pouteau E, Kreis R, Trepp R, Diem P, Boesch C, Decombaz J. IMCL stores increase markedly in athletes after 1.5d lipid supplementation and are utilized during exercise in proportion to their content. Eur.J.Appl.Physiol. 98: 341-354 (2006).

·          Zacharia A, Zimine S, Lovblad KO, Warfield S, Thoeny H, Ozdoba C, Bossi E, Kreis R, Boesch C, Schroth G, Huppi PS. Early assessment of brain maturation by MR imaging segmentation in neonates and premature infants. AJNR Am J Neuroradiol. 27: 972-977 (2006).

·          Hofmann L, Simon-Zoula S, Nowak A, Giger A, Vock P, Boesch C, Frey FJ, Vogt B. BOLD-MRI for the assessment of renal oxygenation in humans: Acute effect of nephrotoxic xenobiotics. Kidney Int. 70: 144-150 (2006).

·          Christ ER, Zehnder M, Boesch C, Trepp R, Mullis PE, Diem P, Decombaz J. The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance trained males. Eur.J.Endocrinol. 154: 397-403 (2006).

·          Yen K, Weis J, Kreis R, Jackowski C, Aghayev E, Boesch C, Maier S, Dirnhofer R, Lövblad KO. Line Scan Diffusion Tensor Imaging of Post-traumatic Brainstem: Changes with Neuropathological Correlation. AJNR 27: 70-73 (2006).

·          Simon-Zoula S, Hofmann L, Giger A, Vogt B, Vock P, Frey FJ, Boesch C. Non invasive monitoring of renal oxygenation using BOLD-MRI: a reproducibility study. NMR Biomed. 19: 84-89 (2006).

·          Jackowski C, Thali M, Aghayev E, Yen K, Sonnenschein M, Zwygart K, Dirnhofer R, Vock P. Postmortem imaging of blood and its characteristics using MSCT and MRI. Int.J.Legal Med. 120: 233-240 (2006).

·          Boesch C. Magnetic Resonance Spectroscopy: Basic Principles. Chapter 17. In: Edelman, RR, Hesselink JR, Zlatkin MB, Crues JV, editors. Clinical Magnetic Resonance Imaging. Philadelphia, PA: Saunders Elsevier, 459-492 (2005).

·          Thoeny HC, De Keyzer F, Vandecaveye V, Chen F, Sun X, Bosmans H, Hermans R, Verbeken EK, Boesch C, Marchal G, Landuyt W, Ni Y. Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 237:492-499 (2005).

·          Kreis R, Slotboom J, Hofmann L, Boesch C. Integrated Data Acquisition and Processing to Determine Metabolite Contents, Relaxation Times, and Macromolecule Baseline in Single Examinations of Individual Subjects. Magn.Reson.Med. 54: 761-768 (2005).

·          Zehnder M, Ith M, Kreis R, Saris W, Boutellier U, Boesch C. Gender-Specific Usage of Intramyocellular Lipids and Glycogen during Exercise. Med.Sci.Sports Exerc. 37: 1517-1524 (2005).

·          Yen K, Thali MJ, Aghayev E, Jackowski C, Schweitzer W, Boesch C, Vock P, Dirnhofer R, Sonnenschein M. Strangulation signs: Initial correlation of MRI, MSCT and forensic neck findings. J.Magn.Reson.Imaging 22: 501-510 (2005).

·          Kreis R, Salvisberg C, Lutz T, Boesch C, Pietz J. Visibility of Vascular Phenylalanine in Dynamic Uptake Studies in Humans using Magnetic Resonance Spectroscopy. Magn.Reson.Med. 54: 435-438 (2005).

·          Stettler R, Ith M, Acheson KJ, Decombaz J, Boesch C, Tappy L, Binnert C. Interaction between dietary lipids and physical inactivity on insulin sensitivity and on intramyocellular lipids in healthy men. Diabetes Care 28: 1404-1409 (2005).

·          Scheurer E, Ith M, Dietrich D, Kreis R, Hüsler J, Dirnhofer R, Boesch C. Statistical evaluation of time-dependent metabolite concentrations: Estimation of post-mortem intervals based on in situ 1H-MRS of the brain. NMR in Biomed. 18: 163-172 (2005).

·          Baumgartner I, Thoeny HC, Kummer O, Roefke C, Skjelsvik C, Boesch C, Kreis R. Leg Ischemia: Assessment with MR Angiography and Spectroscopy. Radiology 234: 833-841 (2005).

·          Yen K, Sonnenschein M, Thali MJ, Ozdoba C, Weis J, Zwygart K, Aghayev E, Jackowski C, Dirnhofer R. Postmortem Multislice Computed Tomography and Magnetic Resonance Imaging of odontoid fractures, atlantoaxial distractions and ascending medullary edema. Int.J.Legal Med. 119: 129-136 (2005).

·          Yen K, Vock P, Tiefenthaler B, Ranner G, Scheurer E, Thali MJ, Zwygart K, Sonnenschein M, Wiltgen M, Dirnhofer R. Virtopsy: forensic traumatology of the subcutaneous fatty tissue; multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) as diagnostic tools. J.Forensic Sci. 49:799-806 (2004).

·          Thoeny HC, De Keyzer F, Boesch C, Hermans R. Diffusion-Weighted Imaging of the Parotid Gland: Influence of the Choice of b-Values on the Apparent Diffusion Coefficient (ADC) Value. J.Magn.Reson.Imaging 20: 786-790 (2004).

·          Kreis R. Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts. NMR Biomed. 17: 361-381 (2004).

·          Boesch C. Nobel Prizes for Nuclear Magnetic Resonance: 2003 and Historical Perspectives (Editorial) J.Magn.Reson.Imaging 20: 177-179 (2004).

·          Hubl D, Koenig T, Strik W, Federspiel A, Kreis R, Boesch C, Maier SE, Schroth G, Loevblad K, Dirks T. The Pathways That Make the Voices: White Matter Changes in Auditory Hallucinations. Arch.Gen.Psychiatry 61: 658-668 (2004).

·          Vermathen P, Kreis R, Boesch C. Distribution of Intra-myocellular Lipids in Human Calf Muscles Determined by MR Spectroscopic Imaging. Magn.Reson.Med. 51: 253-262 (2004)

·          Pietz J, Lutz T, Zwygart K, Hoffmann GF, Ebinger F, Boesch C, Kreis R. Phenylalanine can be detected in brain tissue of healthy subjects by 1H magnetic resonance spectroscopy. J.Inherit.Metab.Dis. 26: 683-691 (2003)

·          Schmitt B, Flück M, Décombaz J, Kreis R, Boesch C, Wittwer M, Graber F, Vogt M, Howald H, Hoppeler H. Transcriptional Adaptations of Lipid Metabolism in Tibialis Anterior Muscle of Endurance Trained Athletes. Physiol.Genomics 15: 148-157 (2003)

·          Plattner T, Thali MJ, Yen K, Sonnenschein M, Stoupis C, Vock P, Zwygart-Brugger K, Kilchor T, Dirnhofer R. Virtopsy-postmortem multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) in a fatal scuba diving incident. J.Forensic Sci. 48: 1347-1355 (2003).

·          Flück CE, Slotboom J, J.M.Nuoffer, Kreis R, Boesch C, P.E.Mullis. Normal Hepatic Glycogen Storage After Fasting and Feeding in Children and Adolescents with Type 1 Diabetes. Pediatr.Diabetes 4: 70-76 (2003).

·          S.Vella, Kreis R, K.O.Lovblad, M.Steinlin. Acute leukoencephalopathy after inhalation of a single dose of heroin. Neuropediatrics 34: 100-104 (2003).

·          Pietz J, Rupp A, F.Ebinger, D.Rating, E.Mayatepek, Boesch C, Kreis R. Cerebral energy metabolism in phenylketonuria: findings by quantitative in vivo 31P MR spectroscopy. Pediatr.Res. 53: 654-662 (2003).

·          M.J.Thali, K.Yen, W.Schweitzer, P.Vock, Boesch C, C.Ozdoba, Schroth G, Ith M, M.Sonnenschein, T.Doernhofer, E.Scheurer, T.Plattner, R.Dirnhofer. Virtopsy, a New Imaging Horizon in Forensic Pathology: Virtual Autopsy by Postmortem Multislice Computed Tomography (MSCT) and Magnetic Resonance Imaging (MRI) - a Feasibility Study. J.For.Sci. 48: 386-403 (2003).

·          Vermathen P, Boesch C, Kreis R. Mapping fiber orientation in human muscle by proton MR spectroscopic imaging. Magn.Reson.Med. 49: 424-432 (2003).

·          Kreis R, Hofmann L, B.Kuhlmann, Boesch C, E.Bossi, P.S.Huppi. Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy. Magn.Reson.Med. 48: 949-958 (2002).

·          Ith M, Bigler P, Scheurer E, Kreis R, Hofmann L, Dirnhofer R, Boesch C. Observation and identification of metabolites emerging during postmortem decomposition of brain tissue by means of in situ 1H-magnetic resonance spectroscopy. Magn.Reson.Med. 48: 915-920 (2002).

·          Pietz J, Rupp A, Burgard P, Boesch C, Kreis R. No evidence for individual blood-brain barrier phenylalanine transport to influence clinical outcome in typical phenylketonuria patients (letter). Ann.Neurol. 52: 382-383 (2002).

·          Hofmann L, Slotboom J, Jung B, Maloca P, Boesch C, Kreis R. Quantitative 1H-magnetic resonance spectroscopy of human brain: influence of composition and parameterization of the basis set in linear combination model fitting. Magn.Reson.Med. 48: 440-453 (2002).

·          Howald H, Boesch C, Kreis R, Matter S, Billeter R, Essen-Gustavsson B, Hoppeler H. Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and 1H-MR spectroscopy. J.Appl.Physiol. 92: 2264-2272 (2002).

·          Wachter S, Vogt M, Kreis R, Boesch C, Bigler P, Hoppeler H, Krahenbuhl S. Long-term administration of L-carnitine to humans: effect on skeletal muscle carnitine content and physical performance. Clin.Chim.Acta 318: 51-61 (2002).

·          Schawalder P, Andres HU, Jutzi K, Stoupis C, Bösch C. [Canine panosteitis: an idiopathic bone disease investigated in the light of a new hypothesis concerning pathogenesis. Part 1: Clinical and diagnostic aspects]. Schweiz.Arch.Tierheilkd. 144: 115-130 (2002).

·          Hofmann L, Slotboom J, Boesch C, Kreis R. Characterization of the macromolecule baseline in localized 1H-MR spectra of human brain. Magn. Reson. Med. 46: 855-863 (2001).

·          Kreis R, Bruegger K, Skjelsvik C, Zwicky S, Ith M, Jung B, Baumgartner I, Boesch C. Quantitative 1H magnetic resonance spectroscopy of myoglobin de- and re-oxygenation in skeletal muscle: Reproducibility and effects of localization and disease. Magn. Reson. Med. 46: 240-248 (2001).

·          Decombaz J, Schmitt B, Ith M, Decarli B, Diem P, Kreis R, Hoppeler H, Boesch C. Post-exercise fat intake repletes intramyocellular lipids, but no faster in trained than in sedentary subjects. Am. J. Physiol. 281: R760-R769 (2001).

·          Boesch C, Ith M, Jung B, Bruegger K, Erban S, Diamantis I, Kreis R, Bär A. Effect of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers. Regul. Toxicol. Pharmacol. 33: 257-267 (2001).

·          Kreis R, Slotboom J, Pietz J, Jung B, Boesch C.  Quantitation of localized 31P magnetic resonance spectra based on the reciprocity principle. J. Magn. Reson. 149: 245-250 (2001).

·          Rupp A, Kreis R, Zschocke J, Slotboom J, Boesch C, Rating D, Pietz J. Variability of blood-brain ratios of phenylalanine in typical patients with phenylketonuria. J. Cereb. Blood Flow Metab. 21: 276-284 (2001).

·          Boesch C, Kreis R. Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle. NMR Biomed. 14: 140-148  (2001).

·          Boesch C. How MRI and MRS can probe tissue microstructure far below the spatial dimensions of a voxel (Editorial). NMR Biomed. 14: 55-56 (2001).

·          Rotman S, Slotboom J, Kreis R, Boesch C, Jéquier E. Muscle glycogen recovery after exercise measured by 13C-MRS in humans: Effect of nutritional solutions. MAGMA 11, 114-121 (2000).

·          Décombaz J, Fleith M, Hoppeler H, Kreis R, Boesch C. Effect of diet on the replenishment of intramyocellular lipids after exercise. Eur. J. Nutr. 39: 244-247 (2000).

·          Boesch C, Kreis R. Observation of intramyocellular lipids (IMCL) by means of 1H-magnetic resonance spectroscopy. Ann.NY Acad.Sci. 904: 25-31 (2000).

·          Kreis R Comments on in vivo proton magnetic resonance spectroscopy in phenylketonuria. Eur. J. Pediatr. 159 (Suppl 2), S126-S128 (2000).

·          Boesch C, Kreis R. Imaging and spectroscopy of muscle. In: Young IR, Grant DM, Harris RK, editors. Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy (Encyclopedia of Nuclear Magnetic Resonance). Chichester UK: John Wiley & Sons, 1307-1315 (2000).

·          Boesch C. Patient Life Support & Montoring Facilities for Whole Body MRI (reprint of book chapter in 'Encyclopedia of NMR'). In: Young IR, Grant DM, Harris RK, editors. Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy (Encyclopedia of Nuclear Magnetic Resonance). Chichester UK: John Wiley & Sons, 193-201 (2000).

·          Kreis R, Jung B, Slotboom J, Felblinger J, Boesch C. Effect of Exercise on the Creatine Resonances in 1H MR Spectra of Human Skeletal Muscle. J. Magn.Reson. 137: 350-357 (1999).

·          Pietz J, Kreis R, Rupp A, Mayatepek E, Rating D, Boesch C, Bremer HJ. Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria. J Clin.Invest. 103: 1169-1178 (1999).Free Full Text Article at

·          Felblinger J, Slotboom J, Kreis R, Jung B, Boesch C. Restoration of electrophysiological signals distorted by inductive effects of magnetic field gradients during MR sequences. Magn. Reson. Med. 41, 715-721 (1999).

·          Boesch C, Décombaz J, Slotboom J, Kreis R. Observation of intramyocellular lipids by means of 1H-magnetic resonance spectroscopy. Proc.Nutr.Soc. 58: 841-850 (1999).

·          Boesch C. Molecular aspects of magnetic resonance imaging and spectroscopy. Mol. Aspects. Med. 20: 185-318 (1999).

·          Felblinger J, Jung B, Slotboom J, Boesch C, Kreis R. Methods and Reproducibility of Cardiac / Respiratory Double-Triggered 1H-MR Spectroscopy of the Human Heart. Magn. Reson. Med. 42, 903-910 (1999).

·          Delon-Martin C, Roth M, Morand S, Massarelli R, Belle V, Decety J, Felblinger J, Decorps M, Segebarth C. MRI measurement of the functional blood flow changes in a large superficial vein draining the motor cortex. NMR Biomed. 12, 107-114 (1999).

·          Fusch C, Slotboom J, Fuehrer U, Schumacher R, Keisker A, Zimmermann W, Moessinger A, Boesch C, Blum J. Neonatal body composition: Dual-energy x-ray absorptiometry, magnetic resonance imaging and three-dimensional chemical shift imaging vs. chemical analysis in piglets. Pediatr. Res. 46: 465-473 (1999).

·          Kamber M, Koster M, Kreis R, Walker G, Boesch C, Hoppeler H. Creatine supplementation and performance. Part I: Physical performance, clinical chemistry, and muscle volume. Med.Sci.Sports Exerc. 31, 1763-1769 (1999).

·          Kreis R, Kamber M, Koster M, Felblinger J, Slotboom J, Hoppeler H, Boesch C. Creatine supplementation and performance. Part II: In vivo magnetic resonance spectroscopy. Med.Sci.Sports Exerc. 31, 1770-1777 (1999).

·          Kreis R, Jung B, Rotman S, Slotboom J, Boesch C. Non-invasive observation of acetyl-group buffering by 1H-MR spectroscopy in exercising human muscle. NMR Biomed. 12, 471-476 (1999).

·          Slotboom J, Boesch C, Kreis R. Versatile frequency domain fitting using time domain models and prior knowledge. Magn.Reson.Med. 39: 899-911 (1998).

·          Kreis R, Felblinger J, Jung B, Boesch C. In vivo 1H-MR spectroscopy of the human heart. MAGMA 6: 164-167 (1998).

·          Ross BD, Ernst T, Kreis R, Haseler LJ, Bayer S, Danielsen E, Bluml S, Shonk T, Mandigo JC, Caton W, Clark C, Jensen SW, Lehman NL, Arcinue E, Pudenz R, and Shelden CH. 1H MRS in acute traumatic brain injury. J.Magn.Reson.Imaging 8:829-840, 1998.

·          Boesch C, Felblinger J. Patient Life Support, Safety and Equipment Compatibility: Life Support. In: F.Jolesz, I.Young, editors. Interventional MR. Martin Dunitz Ltd, London UK, 53-62 (1998).

·          Felblinger J, Boesch C. Patient monitoring in the MR environment. In: J.F.Debatin, G.Adam, editors. Interventional Magnetic Resonance Imaging. Springer-Verlag, Heidelberg, Germany. 105-112 (1998).

·          Müri RM, Felblinger J, Rösler KM, Jung B, Hess CW, Boesch C. Recording of electrical brain activity in a magnetic resonance environment: Distorting effects of the static magnetic field. Magn.Reson.Med. 39: 18-22 (1998).

·          Felblinger J, Kreis R, Boesch C. Effects of physiologic motion of the human brain upon quantitative 1H-MRS: Analysis and correction by retro-gating. NMR Biomed. 11: 107-114 (1998).

·          Boesch C, Elsing C, Wegmüller H, Felblinger J, Vock P, Reichen J. Effect of Ethanol and Fructose on Liver metabolism: A Dynamic 31Phosphorus Magnetic Resonance Spectroscopy Study in Normal Volunteers. Magn. Reson. Imag. 15, 1067-1077 (1997).

·          Boesch C. Magnetresonanz-Spektroskopie in vivo. Labor und Medizin. 24, 245-253 (1997). Text des Artikels verfügbar (German)

·          Hoppeler H, Kayser B, Lindstedt SL, Boesch C, Kushmerick M, Draeger A, Booth F. Recommendations for Muscle Research in Space. Int.J.Sports Med. 18, S280-S282 (1997).

·          Boesch C, Kreis R. MR-spectroscopy (MRS) of different nuclei applied to human muscle: Additional information obtained by 1H-MRS. Int. J. Sports Med. 18, S310-S312 (1997).

·          Kreis R. Quantitative localized 1H MR spectroscopy for clinical use.  Progress in NMR Spectroscopy, 31: 155-195 (1997).

·          Boesch C, Slotboom H, Hoppeler H, Kreis R. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn. Reson. Med. 37, 484-493 (1997).

·          Felblinger J, Boesch C. Amplitude Demodulation of the Electrocardiogram-Signal (ECG) for Respiration Monitoring and Compensation during MR Examinations. Magn. Reson. Med. 38, 129-136 (1997).

·          Kreis R, Koster M, Kamber M, Hoppeler H, Boesch C. Peak assignment in localized 1H MR spectra of human muscle based on oral creatine supplementation. Magn. Reson. Med. 37, 159-163 (1997).

·          Kreis R, Pfenninger J, Boesch C. The role of myo-inositol in hyper-ammionemia: A slow osmotic balancing system? In: C.O.Record, H.AlMardini, editors. Advances in hepatic encephalopathy and metabolism in liver disease. Medical Faculty, University of Newcastle upon Tyne, Newcastle upon Tyne, UK: 40, 289-297 (1997).

·          Ntziachristos V, Kreis R, Boesch C, Quistorff B. Dipolar resonance frequency shifts in 1H-MR spectra of skeletal muscle: Confirmation in rats at 4.7 T in vivo and observation of changes post-mortem. Magn. Reson. Med. 38, 33-39 (1997).

·          Boos N, Dreier D, Hilfiker E, Schade V, Kreis R, Hora J, Aebi M, Boesch C. Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative MRI. J. Orthop. Res. 15, 141-149. (1997).

·          Boos N, Wallin A, Aebi M, Boesch C. A new MR-image analysis method for the measurement of disk height variations. Spine 21, 563-570 (1996).

·          Boesch C. Patient Life Support & Monitoring Facilities for Whole Body MRI. In: Grant DM, Harris RK, editors. Encyclopedia of Nuclear Magnetic Resonance. John Wiley & Sons Ltd, Chichester UK. 3467-3475 (1996).

·          Kreis R, Arcinue E, Ernst T, Shonk TK, Flores R, Ross BD. Hypoxic Encephalopathy after Near-Drowning Studied by Quantitative 1H-Magnetic Resonance Spectroscopy. Metabolic Changes and Their Prognostic Value. J. Clin. Invest. 97, 1142-1154 (1996).  Free Full Text Article at

·          Felblinger J, Müri RM, Ozdoba C, Schroth G, Hess CW, Boesch C. Recordings of eye movements for stimulus control during fMRI by means of electro-oculographic methods. Magn. Reson. Med. 36, 410-414 (1996).

·          Hüppi PS, Schuknecht B, Boesch C, Bossi E, Felblinger J, Fusch C, Herschkowitz N. Structural and Neurobehavioral Delay in Postnatal Brain Development of Preterm Infants. Pediatr. Res. 39, 895-901 (1996).

·          Kreis R, Boesch C. Spatially localized, one- and two-dimensional NMR spectroscopy and in vivo application to human muscle. J. Magn. Reson. Series B. 113, 103-118 (1996).

·          Pietz J, Kreis R, Schmidt H, Meyding-Lamade UK, Rupp A, Boesch C. Phenylketonuria: Findings at MR Imaging and Localized in Vivo H-1 MR Spectroscopy of the Brain in Patients with Early-Treatment. Radiology. 201, 413-420 (1996).

·          Boos N, Boesch C. Quantitative Magnetic Resonance Imaging of the Lumbar Spine. Potential for Investigations of Water Content and Biochemical Composition. Spine 20, 2358-2366 (1995).

·          Felblinger J, Debatin JF, Boesch C, Gruetter R, McKinnon GC. Synchronization device for ECG-gated echo planar imaging. Radiology. 197, 311-313 (1995).

·          Gruetter R, Boesch C. Localization methods for in vivo NMR spectroscopy. Quart. Magn. Reson. Biol. Med. 2, 99-106 (1995).

·          Debatin JF, Davis CP, Felblinger J, McKinnon GC. Evaluation of Ultra Fast Phase Contrast imaging in the Thoracic Aorta. MAGMA 3, 59-66 (1995).

·          Debatin JF, Leung DA, Wildermuth S, Botnar R, Felblinger J, McKinnon GC. Flow Quantitation with Echo-Planar Phase-Contrast Velocity Mapping: In Vitro and In Vivo Evaluation. J. Magn. Reson. Imag. 5, 656-662 (1995).

·          Hüppi PS, Fusch C, Boesch C, Burri R, Bossi E, Amato M, Herschkowitz N. Regional metabolic assessment of human brain during development by proton magnetic resonance spectroscopy in vivo and by high-performance liquid chromatography / gas chromatography in autopsy tissue. Pediatr. Res. 37, 145-150 (1995).

·          Ross BD, Ernst T, Kreis R. Proton Magnetic Resonance Spectroscopy in Hypoxic-Ischemic Disorders. E.N.Faerber, editor. CNS Magnetic Resonance Imaging in Infants & Children. Cambridge University Press, Cambridge UK: 12, 279-306 (1995).

·          Kreis R, Pietz J, Penzien J, Herschkowitz N, Boesch C. Identification and quantitation of phenylalanine in the brain of patients with phenyketonuria by means of localized in vivo 1H magnetic resonance spectroscopy. J. Magn. Reson. Series B. 107, 242-251 (1995).

·          Kreis R, Pfenninger J, Herschkowitz N, Boesch C. In vivo proton magnetic resonance spectroscopy in a case of Reye's syndrome. Intensive Care Med. 21, 266-268 (1995).

·          Pietz J, Kreis R, Boesch C, Penzien J, Rating D, Herschkowitz N. The Dynamics of Brain Concentrations of Phenylalanine and Its Clinical Significance in Patients with Phenylketonuria Determined by in Vivo 1H Magnetic Resonance. Pediatr. Res. 38, 657-663 (1995).

·          Boos N, Wallin A, Schmucker T, Aebi M, Boesch C. Quantitative MR imaging of lumbar intervertebral discs and vertebral bodies: Methodology, reproducibility, and preliminary results. Magn. Reson. Imag. 12, 577-587 (1994).

·          Felblinger J, Lehmann C, Boesch C. Electrocardiogram Acquisition during MR Examinations for Patient Monitoring and Sequence Triggering. Magn. Reson. Med. 32, 523-529 (1994).

·          Ross BD, Jacobson S, Villamil F, Korula J, Kreis R, Ernst T, Shonk T, Moats RA. Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology 193, 457-463 (1994).

·          Kreis R, Boesch C. Liquid-crystal-like structures of human muscle demonstrated by in vivo observation of direct dipolar coupling in localized proton magnetic resonance spectroscopy. J. Magn. Reson. Series B. 104, 189-192 (1994).

·          Boos N, Wallin A, Gbedegbegnon T, Aebi M, Boesch C. Quantitative MR imaging of lumbar intervertebral disks and vertebral bodies: Influence of diurnal water content variations. Radiology. 188, 351-354 (1993).

·          Gruetter R, Fusch C, Martin E, Boesch C. Determination of Saturation Factors in 31P NMR Spectra of the Developing Human Brain. Magn. Reson. Med. 29, 7-11 (1993).

·          Kreis R, Ernst T, Ross BD. Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn. Reson. Med. 30, 424-437 (1993).

·          Gruetter R, Boesch C. Fast, Noniterative Shimming of Spatially Localized Signals. In vivo Analysis of the Magnetic Field along Axes. J. Magn. Reson. 96, 323-334 (1992).

·          Cady EB, Boesch C, Martin E. Magnetic resonance spectroscopy. In: J. Haddad, E. Saliba, editors. Perinatal Asphyxia. Springer, Berlin, 166-194  (1993).

·          Boesch C, Gruetter R, Martin E. Temporal and Spatial Analysis of Fields Generated by Eddy Currents in Superconducting Magnets: Optimization of Corrections and Quantitative Characterization of Magnet / Gradient System. Magn. Reson. Med. 20, 268-284 (1991).

·          Boesch C, Fusch C, Gruetter R, Martin E. Magnetic-resonance examinations of neonates and infants in small-bore systems. In: Lafeber HN, Aarnoudse JG, Jongsma HW, editors. Fetal and Neonatal Physiological Measurements. Elsevier, Excerpta Medica, Amsterdam, 325-31 (1991).

·          Hueppi PS, Posse S, Lazeyras F, Burri R, Boesch C, Bossi E, Amato M, Herschkowitz N. Developmental changes in 1H-spectroscopy in human brain. In: Lafeber HN, Aarnoudse JG, Jongsma HW, editors. Fetal and Neonatal Physiological Measurements. Elsevier, Excerpta Medica, Amsterdam, 33-37 (1991).